Taste Reactivity in Alcohol Preferring and Nonpreferring Rats
نویسندگان
چکیده
منابع مشابه
A comparison of the reinforcing efficacy of alcohol in alcohol-preferring (P) and alcohol-nonpreferring (NP) rats.
A key feature of the selective breeding program that produced alcohol-preferring (P) and alcohol-nonpreferring (NP) rats is that the alcohol was mixed with water. However, humans typically drink sweetened or palatably flavored alcohol. The experiments in this study tested whether the differences in P and NP rats generalize to sweetened alcohol. In Experiment 1, P rats drank more alcohol than NP...
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Individual differences in ethanol preference may be linked to differences in the functional activity of forebrain monoamine systems or their sensitivity to modification by ethanol. To test this hypothesis, basal extracellular concentrations of dopamine (DA) and serotonin (5-HT) in the nucleus accumbens as well as the effects of repeated ethanol pretreatment on the basal release of these transmi...
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BACKGROUND Transient overexpression of the dopamine D2 receptor (DRD2) gene in the nucleus accumbens (NAc) using an adenoviral vector has been associated with a significant decrease in alcohol intake in Sprague Dawley rats. This overexpression of DRD2 reduced alcohol consumption in a two-bottle-choice paradigm and supported the view that high levels of DRD2 may be protective against alcohol abu...
متن کاملLine differences in ethanol consumption and immobility in the forced swim test, but not in stress reactivity, in alcohol preferring (P) and nonpreferring (NP) rats
There is evidence to support a relationship between stress, depression, and alcoholism. Animal models have been developed to ascertain the impact of stress on depressive-like symptoms and ethanol intake. The swim test susceptible (SUS) line of rats selectively bred for enhanced susceptibility to stress-induced immobility in the forced swim test (FST) also show high voluntarily ethanol intake co...
متن کاملFat-preferring rats consume more alcohol than carbohydrate-preferring rats.
Rats with a genetic preference for alcohol (ETOH) have been found to consume more dietary fat then ETOH nonpreferring rats. We therefore hypothesized that rats selected on the basis of fat and carbohydrate (CHO) preferences would differ in ETOH intake. Patterns of macronutrient self-selection were determined by allowing rats to select diets from separate sources of CHO, fat and protein. Subsequ...
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ژورنال
عنوان ژورنال: Alcoholism: Clinical and Experimental Research
سال: 1990
ISSN: 0145-6008,1530-0277
DOI: 10.1111/j.1530-0277.1990.tb01234.x